[[File: Sack of Rome Two.jpg |thumbnail|left|
600px|Portrait of Emperor Charles V, 1527]]
The Sack of Rome was the capture and the destruction of Rome by the mutinous troops of Emperor Charles V. It caused widespread outrage at the time and it shocked Europe. The Sack destroyed much of Rome and it is widely seen as ushering in a new era in the history of Italy. This article will discuss the impact that the Sack had on Italy and its development. The article will discuss the commonly held belief that it ended the Renaissance in Italy. The piece will show that the Sack of Rome in 1527 was of critical importance in the history of Italy and it guaranteed Spanish supremacy in Italy, led to increasingly religious orthodoxy and destroyed the economy of Rome and these all contributed to the ending of the Renaissance.