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It follows the leader of a criminal gang tied to the political establishment in New York City. ‘Bill the Butcher,’ played by the Anglo-Irish actor Daniel Day-Lewis rules the Five-Points. The character is a ‘Nativist’ and wants America to remain a white Anglo-Saxon Protestant country. He despises the recent and numerous Catholic emigrants in New York.

The movie starts with Bill the Butcher killing an Irish gang named Priest Vallon, played by Liam Nesson in the 1850s. The 'Priest' s son Amsterdam Vallon returns to the Five-Points, and plots revenge against Bill the Butcher for killing his father during the American Civil War. Di Caprio’s character successfully ingratiates himself into Bill's mob, but he does not reveal his true identity.