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The Fall of the capital of the Byzantine world raised the threat level posed by the Ottomans to Italy. For several decades after the capture of Constantinople, the Italian states lived in the shadow of the Ottomans. The end of the Byzantine Empire was a catastrophe for Venice and Genoa. The loss of trade and the persistent attacks from the Turkish Sultans led to the decline of both city-states. The Fall of Constantinople for Genoa led to a crisis that severely weakened the Republic. In the case of Venice is led to a period of relative decline as the city had to fight regular costly wars with the Turks.
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