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However, at the time, they proved enormously influential on the development of Renaissance sculpture. The Florentine was also interested in architecture and helped to design the cupola for the Cathedral in Milan. He wrote an unpublished treatise on architecture and produced many architectural drawings.<ref>Kemp, Martin. Leonardo da Vinci: the marvelous works of nature and man (Oxford, Oxford, University Press, 2007), p 113</ref> These inspired many architects, including the great Bramante.

Da Vinci was fascinated by science, engineering, and mechanics. He wrote about these subjects copiously in his notebooks. His theory of knowledge was based on the study of nature. Leonardo was also intrigued by the human body and he is believed to have dissected up to 30 human bodies and made many anatomical drawings.