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There are a select number of literary works whose characters have entered the public imagination. One of these is the ‘Strange Case of Dr. Jekyll and Mr. Hyde’. This work on the nature of good and evil in human nature has spawned countless movies, plays, television shows, comics, and movies. The two main characters have come to represent the duality of human nature and split personalities. Dr. Jekyll and Mr. Hyde, although written in the 19th century is still as relevant today, as over a century ago. This article discusses the possible sources that inspired Robert Louis Stevenson to write a great horror story. It will examine the possible literary sources for the classic of the supernatural genre. Then it identifies possible candidates for the real-life characters who inspired Dr. Jekyll and Mr. Hyde.