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[[File: Pope Clement VII.jpg|thumbnail|300px200px|left|Pope Clement VII in 1528]]
Emperor Charles V was deeply embarrassed by the actions of his mutinous army. However, Charles knew that the Pope was in a weak position and he saw it as an opportunity to extend his control over the Papacy.<ref> Chastel. p. 212</ref>. Successive Popes, eager to preserve Italian independence and their own had allied themselves with the French, to prevent Charles from upsetting the balance of power in Italy. Charles V now used the weakened position of Pope Clement to ensure that the Papacy was no longer able to resist Imperial interests in Italy. After the Sack of Rome, Pope Clement was too afraid of Charles V after the Sack to adopt a policy that was independent of the Emperor. This policy was to have momentous consequences not only for the Church but also for the history of Europe. In the aftermath of the Sack, the Popes were very reluctant to go against the wishes of the Emperor and after his abdication, the Spanish monarchs, who inherited the greatest part of Charles V territories<ref> Tuchman, p. 347</ref>.

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